View: BIODESIGN GROUP 2
The schematic shown above is a representation of the potential of mesenchymal stem cells (MSC) in the bone marrow. The development of mature cells such as adipocytes and osteoblasts proceeds through progenitor cells. Mechanical biasing of MSC lineage selection suggest that physical signals influence the quantity of both bone and fat. The mechanical signals have been reported to influence the differentiation of MSC to become osteoblasts rather than adipocytes. In other words, the biasing of MSC differentiation by these mechanical signals represents a unique means in which adiposity can be inhibited while simultaneously promoting bone quality, better skeleton.